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Article

Intermittent montelukast in children aged 10 months to 5 years with wheeze (WAIT trial): a multicentre, randomised, placebo-controlled trial.

The Lancet. Respiratory medicine - 1 Oct 2014

Nwokoro Chinedu, Pandya Hitesh, Turner Stephen, Eldridge Sandra, Griffiths Christopher J, Vulliamy Tom, Price David, Sanak Marek, Holloway John W, Brugha Rossa, Koh Lee, Dickson Iain, Rutterford Clare, Grigg Jonathan

Abstract excerpt

BACKGROUND: The effectiveness of intermittent montelukast for wheeze in young children is unclear. We aimed to assess whether intermittent montelukast is better than placebo for treatment of wheeze in this age group. Because copy numbers of the Sp1-binding motif in the arachidonate 5-lipoxygenase (ALOX5) gene promoter (either 5/5, 5/x, or x/x, where x does not equal 5) modifies response to montelukast in adults,...

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Identifiers

PMID: 25212745
DOI: 10.1016/S2213-2600(14)70186-9
PMCID: PMC4189104

Genes

ALOX5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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