Article
Disruption of Visc-2, a Brain-Expressed Conserved Long Noncoding RNA, Does Not Elicit an Overt Anatomical or Behavioral Phenotype.
Cerebral cortex (New York, N.Y. : 1991) - 1 Oct 2015
Oliver Peter L, Chodroff Rebecca A, Gosal Amrit, Edwards Benjamin, Cheung Amanda F P, Gomez-Rodriguez Julio, Elliot Gene, Garrett Lisa J, Lickiss Tom, Szele Francis, Green Eric D, Molnár Zoltán, Ponting Chris P
Abstract excerpt
Although long noncoding RNAs (lncRNAs) are proposed to play essential roles in mammalian neurodevelopment, we know little of their functions from their disruption in vivo. Combining evidence for evolutionary constraint and conserved expression data, we previously identified candidate lncRNAs that might play important and conserved roles in brain function. Here, we demonstrate that the sequence and neuronal...
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