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Article

Characterization of the rs2802292 SNP identifies FOXO3A as a modifier locus predicting cancer risk in patients with PJS and PHTS hamartomatous polyposis syndromes.

BMC cancer - 11 Sept 2014

Forte Giovanna, Grossi Valentina, Celestini Valentina, Lucisano Giuseppe, Scardapane Marco, Varvara Dora, Patruno Margherita, Bagnulo Rosanna, Loconte Daria, Giunti Laura, Petracca Antonio, Giglio Sabrina, Genuardi Maurizio, Pellegrini Fabio, Resta Nicoletta, Simone Cristiano

Abstract excerpt

BACKGROUND: Hamartomatous polyposis syndromes (HPS) are inherited conditions associated with high cancer risk. They include the Peutz-Jeghers and the PTEN hamartoma tumor syndromes, which are caused by mutations in the LKB1 and PTEN genes, respectively. Estimation of cancer risk is crucial in order to optimize surveillance, but no prognostic markers are currently available for these conditions. Our study relies...

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PMID: 25208626
DOI: 10.1186/1471-2407-14-661
PMCID: PMC4167262

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PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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