Article
Genetic, anatomic, and clinical determinants of human serum sterol and vitamin D levels.
Proceedings of the National Academy of Sciences of the United States of America - 23 Sept 2014
Stiles Ashlee R, Kozlitina Julia, Thompson Bonne M, McDonald Jeffrey G, King Kevin S, Russell David W
Abstract excerpt
An unknown fraction of the genome participates in the metabolism of sterols and vitamin D, two classes of lipids with diverse physiological and pathophysiological roles. Here, we used mass spectrometry to measure the abundance of >60 sterol and vitamin D derivatives in 3,230 serum samples from a well-phenotyped patient population. Twenty-nine of these lipids were detected in a majority of samples at levels that...
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