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Article

The Role of miRNA in Papillary Thyroid Cancer in the Context of miRNA Let-7 Family.

International journal of molecular sciences - 15 Jun 2016

Perdas Ewelina, Stawski Robert, Nowak Dariusz, Zubrzycka Maria

Abstract excerpt

Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy. RET/PTC rearrangement is the most common genetic modification identified in this category of cancer, increasing proliferation and dedifferentiation by the activation of the RET/PTC-RAS-BRAF-MAPK-ERK signaling pathway. Recently, let-7 miRNA was found to reduce RAS levels, acting as a tumor suppressor gene. Circulating miRNA profiles of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27314338
DOI: 10.3390/ijms17060909
PMCID: PMC4926443

Genes

RET
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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