Article
Differences in proliferative capacity of primary human acute myelogenous leukaemia cells are associated with altered gene expression profiles and can be used for subclassification of patients.
Cell proliferation - 1 Oct 2013
Reikvam H, Øyan A M, Kalland K H, Hovland R, Hatfield K J, Bruserud Ø
Abstract excerpt
OBJECTIVES: Proliferative capacity of acute myelogenous leukaemia (AML) blasts is important for leukaemogenesis, and we have investigated whether proliferative capacity of primary human AML cells could be used for subclassification of patients. MATERIALS AND METHODS: In vitro proliferative capacity of AML cells derived from two independent groups was investigated. Cells were cultured under highly standardized...
Topics
- Adult
- Aged
- Aged, 80 and over
- Autocrine Communication
- Cell Proliferation
- Cluster Analysis
- Computational Biology
- Cytokines
- Female
- Gene Duplication
- Humans
- Leukemia, Myeloid, Acute
- Male