Germline polymorphisms and survival of lung adenocarcinoma patients: a genome-wide study in two European patient series.

doi:10.1002/ijc.29195

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Germline polymorphisms and survival of lung adenocarcinoma patients: a genome-wide study in two European patient series.

International journal of cancer - 1 Mar 2015

Galvan Antonella, Colombo Francesca, Frullanti Elisa, Dassano Alice, Noci Sara, Wang Yufei, Eisen Timothy, Matakidou Athena, Tomasello Luisa, Vezzalini Marzia, Sorio Claudio, Dugo Matteo, Ambrogi Federico, Iacobucci Ilaria, Martinelli Giovanni, Incarbone Matteo, Alloisio Marco, Nosotti Mario, Tosi Davide, Santambrogio Luigi, Pelosi Giuseppe, Pastorino Ugo, Houlston Richard S, Dragani Tommaso A

Abstract excerpt

In lung cancer, the survival of patients with the same clinical stage varies widely for unknown reasons. In this two-phase study, we examined the hypothesis that germline variations influence the survival of patients with lung adenocarcinoma. First, we analyzed existing genotype and clinical data from 289 UK-resident patients with lung adenocarcinoma, identifying 86 single nucleotide polymorphisms (SNPs) that...

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PMID: 25196286
DOI: 10.1002/ijc.29195

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