Article
Vitamin D receptor gene polymorphisms in relation to the risk of colorectal cancer in the Polish population.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Dec 2014
Laczmanska Izabela, Laczmanski Lukasz, Bebenek Marek, Karpinski Pawel, Czemarmazowicz Halina, Ramsey David, Milewicz Andrzej, Sasiadek Maria M
Abstract excerpt
The protective effect of vitamin D against several cancers including colorectal cancer is modulated by the vitamin D receptor (VDR) and its ligand, the active form of vitamin D. VDR response has been found to play a role in various genes encoding proteins involved in crucial cellular pathways. Single nucleotide polymorphisms (SNPs) of the VDR gene that modulate its activity are located in the promoter region,...
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