Article
Association between interleukin 8 -251 A/T and +781 C/T polymorphisms and osteoarthritis risk.
Immunology letters - 1 Nov 2014
He Yu, Liang XinJun, Wu Xinghuo, Meng ChunQing, Wu Bin, Fu Dehao, Jin Shengyang, Yang ShuHua, Wang Hong
Abstract excerpt
PURPOSE: Interleukin 8 (IL-8), as a member of the CXC chemokine family, has a regulatory role in joint inflammation and cartilage degradation, and contribute to the pathophysiology of osteoarthritis. The aim of the current study was to examine the influence of the IL-8 gene polymorphisms at positions -251 (rs4073) and +781 (rs2227306) on the risk of osteoarthritis. METHODS: This hospital-based case-control study...
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