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Tyrosine Kinase Inhibitors as Reversal Agents for ABC Transporter Mediated Drug Resistance

4 Sept 2014

Abstract excerpt

Tyrosine kinases (TKs) play an important role in pathways that regulate cancer cell proliferation, apoptosis, angiogenesis and metastasis. Aberrant activity of TKs has been implicated in several types of cancers. In recent years, tyrosine kinase inhibitors (TKIs) have been developed to interfere with the activity of deregulated kinases. These TKIs are remarkably effective in the treatment of various human cancers...

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PMID: 25191874
DOI: 10.3390/molecules190913848

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