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Interaction of Tyrosine Kinase Inhibitors with the MDR-Related ABC Transporter Proteins

1 Sept 2010

Abstract excerpt

Tyrosine kinase inhibitors (TKIs) are a new class of highly-selective and molecularly targeted anticancer agents. Most of these newly developed TKIs are hydrophobic, thus allowing them to rapidly penetrate the cell membrane to reach their specific intracellular targets. However, their therapeutic potential could be significantly hindered by the overexpression of certain ATP binding cassette (ABC) membrane...

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PMID: 20812904
DOI: 10.2174/138920010792927316

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