Article

Mechanisms of acquired resistance to tyrosine kinase inhibitors

2011-11-18

Abstract excerpt

In recent years, structural and functional studies reveal that tyrosine kinases (TKs) act as the essential components of signal transduction pathways that regulate cancer cell proliferation, apoptosis and angiogenesis, and therefore become potential targets for anticancer therapy. Most of TK inhibitors (TKIs) are small molecular and hydrophobic compounds, thus they can rapidly reach their specific intracellular ta...

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Literature Corpus work: bdd3053e-6775-5281-ac19-c8fb263da5b5
DOI: 10.1016/j.apsb.2011.10.007

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