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Epstein–Barr virus‐encoded EBNA1 and ZEBRA : targets for therapeutic strategies against EBV ‐carrying cancers

4 Sept 2014

Abstract excerpt

The EBV-encoded EBNA1 was first discovered 40 years ago, approximately 10 years after the presence of EBV had been demonstrated in Burkitt's lymphoma cells. It took another 10 years before the functions of EBNA1 in maintaining the viral genome were revealed, and it has since been shown to be an essential viral factor expressed in all EBV-carrying cells. Apart from serving to maintain the viral episome and to...

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PMID: 25186125
DOI: 10.1002/path.4431

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