Article
Membrane topology and intracellular processing of cyclin M2 (CNNM2).
The Journal of biological chemistry - 20 Apr 2012
de Baaij Jeroen H F, Stuiver Marchel, Meij Iwan C, Lainez Sergio, Kopplin Kathrin, Venselaar Hanka, Müller Dominik, Bindels René J M, Hoenderop Joost G J
Abstract excerpt
Recently, mutations in the cyclin M2 (CNNM2) gene were identified to be causative for severe hypomagnesemia. In kidney, CNNM2 is a basolaterally expressed protein with predominant expression in the distal convoluted tubule. Transcellular magnesium (Mg(2+)) reabsorption in the distal convoluted tubule represents the final step before Mg(2+) is excreted into the urine, thus fine-tuning its final excretion via a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.