Article
A fault-tolerant method for HLA typing with PacBio data.
BMC bioinformatics - 3 Sept 2014
Chang Chia-Jung, Chen Pei-Lung, Yang Wei-Shiung, Chao Kun-Mao
Abstract excerpt
BACKGROUND: Human leukocyte antigen (HLA) genes are critical genes involved in important biomedical aspects, including organ transplantation, autoimmune diseases and infectious diseases. The gene family contains the most polymorphic genes in humans and the difference between two alleles is only a single base pair substitution in many cases. The next generation sequencing (NGS) technologies could be used for high...
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