Article
Inhibition of the MDM2 E3 Ligase induces apoptosis and autophagy in wild-type and mutant p53 models of multiple myeloma, and acts synergistically with ABT-737.
PloS one - 1 Jan 2014
Gu Dongmin, Wang Shuhong, Kuiatse Isere, Wang Hua, He Jin, Dai Yun, Jones Richard J, Bjorklund Chad C, Yang Jing, Grant Steven, Orlowski Robert Z
Abstract excerpt
Intracellular proteolytic pathways have been validated as rational targets in multiple myeloma with the approval of two proteasome inhibitors in this disease, and with the finding that immunomodulatory agents work through an E3 ubiquitin ligase containing Cereblon. Another E3 ligase that could be a rational target is the murine double minute (MDM) 2 protein, which plays a role in p53 turnover. A novel inhibitor...
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