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Article

Molecular Mechanisms of p53 Deregulation in Cancer: An Overview in Multiple Myeloma.

International journal of molecular sciences - 30 Nov 2016

Herrero Ana B, Rojas Elizabeta A, Misiewicz-Krzeminska Irena, Krzeminski Patryk, Gutiérrez Norma C

Abstract excerpt

The p53 pathway is inactivated in the majority of human cancers. Although this perturbation frequently occurs through the mutation or deletion of p53 itself, there are other mechanisms that can attenuate the pathway and contribute to tumorigenesis. For example, overexpression of important p53 negative regulators, such as murine double minute 2 (MDM2) or murine double minute 4 (MDM4), epigenetic deregulation, or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-mdm2

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Source

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Identifiers

PMID: 27916892
DOI: 10.3390/ijms17122003
PMCID: PMC5187803

Genes

MDM2
MDM4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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