Article
H558R polymorphism in SCN5A is associated with Keshan disease and QRS prolongation in Keshan disease patients.
Genetics and molecular research : GMR - 28 Aug 2014
Jiang S, Li F L, Dong Q, Liu H W, Fang C F, Shu C, Cheng H, Cui J, Ma H X, Chen D Q, Li H
Abstract excerpt
Keshan disease (KSD), a potentially fatal cardiomyopathy, has very high incidence in some selenium-poor regions of China. KSD may be accompanied with a variety of arrhythmia, which is associated with mutations in the gene coding for cardiac voltage-gated sodium channel (SCN5A). The molecular mechanism of KSD is still largely obscure. We aimed to determine the association between the H558R polymorphism of SCN5A...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.