Article
Is sudden unexplained nocturnal death syndrome in Southern China a cardiac sodium channel dysfunction disorder?
Forensic science international - 1 Mar 2014
Liu Chao, Tester David J, Hou Yiding, Wang Wen, Lv Guoli, Ackerman Michael J, Makielski Jonathan C, Cheng Jianding
Abstract excerpt
Sudden unexplained nocturnal death syndrome (SUNDS) remains an enigma to both forensic pathologists and physicians. Previous epidemiological, clinical, and pilot genetic studies have implicated that SUNDS is most likely a disease allelic to Brugada syndrome (BrS). We have performed postmortem genetic testing to address the spectrum and role of genetic abnormalities in the SCN5A-encoded cardiac sodium channel and...
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