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Article

Microenvironment and brain tumor stem cell maintenance: impact of the niche.

Anti-cancer agents in medicinal chemistry - 1 Jan 2014

Herold-Mende Christel, Mock Andreas

Abstract excerpt

There is a lot of experimental evidence that brain tumors might be sustained by a subpopulation of immature cells, so-called brain tumor stem cells (BTSCs), which do not only drive tumor formation but are highly resistant to conventional therapies. Recent findings suggest a critical role of the molecular and cellular tumor microenvironment in which these cells reside for the maintenance of stem cell properties...

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Identifiers

PMID: 25175691
DOI: 10.2174/1871520614666140825103636

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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