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Article

Nuclear localized Influenza nucleoprotein N-terminal deletion mutant is deficient in functional vRNP formation.

Virology journal - 31 Aug 2014

Sanchez Abel, Guerrero-Juarez Christian F, Ramirez Jose, Newcomb Laura L

Abstract excerpt

BACKGROUND: The influenza RNA dependent RNA polymerase synthesizes viral RNA in the nucleus as functional viral ribonucleoprotein (vRNP) complexes with RNA and nucleoprotein (NP). The N-terminus of NP contains an unconventional nuclear localization signal (NLS) important for initial vRNP nuclear localization but which also interacts with various host factors. METHODS: To study the role of the N-terminus of NP...

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Identifiers

PMID: 25174360
DOI: 10.1186/1743-422X-11-155
PMCID: PMC4177073

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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