Article
Tumor necrosis factor beta NcoI polymorphism is associated with inflammatory and metabolic markers in multiple sclerosis patients.
Journal of the neurological sciences - 15 Nov 2014
Kallaur Ana Paula, Oliveira Sayonara Rangel, Simão Andréa Name Colado, de Almeida Elaine Regina Delicato, Morimoto Helena Kaminami, Alfieri Daniela Frizon, Pereira Wildea Lice de Carvalho Jennings, Borelli Sueli Donizete, Kaimen-Maciel Damácio Ramon, Maes Michael, Reiche Edna Maria Vissoci
Abstract excerpt
To evaluate the association between the tumor necrosis factor beta (TNF-β) NcoI polymorphism and inflammatory and metabolic markers in patients with multiple sclerosis (MS) patients and the association of these markers with disease disability, a 782 base-pair fragment of the TNF-β gene was amplified from genomic DNA and digested with the NcoI restriction enzyme. The serum levels of numerous cytokines (IL-1β,...
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