Article
SeqControl: process control for DNA sequencing.
Nature methods - 1 Oct 2014
Chong Lauren C, Albuquerque Marco A, Harding Nicholas J, Caloian Cristian, Chan-Seng-Yue Michelle, de Borja Richard, Fraser Michael, Denroche Robert E, Beck Timothy A, van der Kwast Theodorus, Bristow Robert G, McPherson John D, Boutros Paul C
Abstract excerpt
As high-throughput sequencing continues to increase in speed and throughput, routine clinical and industrial application draws closer. These 'production' settings will require enhanced quality monitoring and quality control to optimize output and reduce costs. We developed SeqControl, a framework for predicting sequencing quality and coverage using a set of 15 metrics describing overall coverage, coverage...
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