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Article

SeqQC-former: A sequence-quality fusion framework for QC-aware review prioritization of candidate somatic SNVs in cancer genomics.

Computational biology and chemistry - 1 Dec 2026

Zubair Muhammad, Li Jianqiang, Wang Zitong, Qian Jun

Abstract excerpt

The accurate prioritization of candidate somatic single-nucleotide variants (SNVs) remains a challenge due to the substantial variability in sequencing quality across genomic loci. SeqQC-Former is a sequence-quality fusion framework that integrates the local nucleotide context with read-level quality-control (QC) covariates derived from matched tumor-normal sequencing data. This integration generates QC-aware...

Read the complete abstract on PubMed

Topics

Humans
Genomics
Neoplasms
Polymorphism, Single Nucleotide
Quality Control

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Identifiers

PMID: 42648276
DOI: 10.1016/j.compbiolchem.2026.109348

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