Article
Common variants near ABCA1 and in PMM2 are associated with primary open-angle glaucoma.
Nature genetics - 1 Oct 2014
Chen Yuhong, Lin Ying, Vithana Eranga N, Jia Liyun, Zuo Xianbo, Wong Tien Yin, Chen Li Jia, Zhu Xianjun, Tam Pancy O S, Gong Bo, Qian Shaohong, Li Zheng, Liu Xiaoqi, Mani Baskaran, Luo Qian, Guzman Celeste, Leung Christopher K S, Li Xiaobo, Cao Wenjun, Yang Quanyao, Tham Clement C Y, Cheng Yilian, Zhang Xuejun, Wang Ningli, Aung Tin, Khor Chiea Chuen, Pang Chi Pui, Sun Xinghuai, Yang Zhenglin
Abstract excerpt
We performed a genome-wide association study for primary open-angle glaucoma (POAG) in 1,007 cases with high-pressure glaucoma (HPG) and 1,009 controls from southern China. We observed genome-wide significant association at multiple SNPs near ABCA1 at 9q31.1 (rs2487032; P = 1.66 × 10(-8)) and suggestive evidence of association in PMM2 at 16p13.2 (rs3785176; P = 3.18 × 10(-6)). We replicated these findings in a...
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