Article
Common variants near ABCA1, AFAP1 and GMDS confer risk of primary open-angle glaucoma.
Nature genetics - 1 Oct 2014
Gharahkhani Puya, Burdon Kathryn P, Fogarty Rhys, Sharma Shiwani, Hewitt Alex W, Martin Sarah, Law Matthew H, Cremin Katie, Bailey Jessica N Cooke, Loomis Stephanie J, Pasquale Louis R, Haines Jonathan L, Hauser Michael A, Viswanathan Ananth C, McGuffin Peter, Topouzis Fotis, Foster Paul J, Graham Stuart L, Casson Robert J, Chehade Mark, White Andrew J, Zhou Tiger, Souzeau Emmanuelle, Landers John, Fitzgerald Jude T, Klebe Sonja, Ruddle Jonathan B, Goldberg Ivan, Healey Paul R, Mills Richard A, Wang Jie Jin, Montgomery Grant W, Martin Nicholas G, RadfordSmith Graham, Whiteman David C, Brown Matthew A, Wiggs Janey L, Mackey David A, Mitchell Paul, MacGregor Stuart, Craig Jamie E
Abstract excerpt
Primary open-angle glaucoma (POAG) is a major cause of irreversible blindness worldwide. We performed a genome-wide association study in an Australian discovery cohort comprising 1,155 cases with advanced POAG and 1,992 controls. We investigated the association of the top SNPs from the discovery stage in two Australian replication cohorts (932 cases and 6,862 controls total) and two US replication cohorts (2,616...
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