Article
Downregulation of Wnt causes root resorption.
American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics - 1 Sept 2014
Lim Won Hee, Liu Bo, Hunter Daniel J, Cheng Du, Mah Su-jung, Helms Jill A
Abstract excerpt
INTRODUCTION: There are multiple causes of external root resorption, but absent a disease state, it is most often observed when excessive physical force is used during orthodontic treatment. Even without mechanical stimulation, however, root resorption can still occur. The purpose of this study was to test whether Wnt signaling plays a role in pathologic root resorption, by conditionally deleting Wntless (Wls)...
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