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Article

Origins of Alterations to Rankl Null Mutant Mouse Dental Root Development.

International journal of molecular sciences - 23 Mar 2020

Gama Andrea, Vargas-Franco Jorge William, Sánchez Mesa Diana Carolina, Restrepo Bedoya Elizabeth, Amiaud Jérome, Babajko Sylvie, Berdal Ariane, Acevedo Ana Carolina, Heymann Dominique, Lézot Frédéric, Castaneda Beatriz

Abstract excerpt

The purpose of the present study was to assess the early stages of development of mouse first molar roots in the osteopetrotic context of RANKL invalidation in order to demonstrate that the radicular phenotype observed resulted not only from defective osteoclasts, but also from loss of cell-to-cell communication among dental, periodontium and alveolar bone cells involving RANKL signaling. Two experimental models...

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Identifiers

PMID: 32209985
DOI: 10.3390/ijms21062201
PMCID: PMC7139335

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