Article
Microbiota-induced tissue signals regulate ILC3-mediated antigen presentation.
Nature communications - 14 Apr 2020
Lehmann Frank Michael, von Burg Nicole, Ivanek Robert, Teufel Claudia, Horvath Edit, Peter Annick, Turchinovich Gleb, Staehli Daniel, Eichlisberger Tobias, Gomez de Agüero Mercedes, Coto-Llerena Mairene, Prchal-Murphy Michaela, Sexl Veronika, Bentires-Alj Mohamed, Mueller Christoph, Finke Daniela
Abstract excerpt
Although group 3 innate lymphoid cells (ILC3s) are efficient inducers of T cell responses in the spleen, they fail to induce CD4+ T cell proliferation in the gut. The signals regulating ILC3-T cell responses remain unknown. Here, we show that transcripts associated with MHC II antigen presentation are down-modulated in intestinal natural cytotoxicity receptor (NCR)- ILC3s. Further data implicate...
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