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Article

Human satellite cells have regenerative capacity and are genetically manipulable

25 Aug 2014

Abstract excerpt

Muscle satellite cells promote regeneration and could potentially improve gene delivery for treating muscular dystrophies. Human satellite cells are scarce; therefore, clinical investigation has been limited. We obtained muscle fiber fragments from skeletal muscle biopsy specimens from adult donors aged 20 to 80 years. Fiber fragments were manually dissected, cultured, and evaluated for expression of myogenesis...

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PMID: 25157816
DOI: 10.1172/jci63992

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