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Article

Continuous subcutaneous IGF-1 therapy via insulin pump in a patient with Donohue syndrome.

Journal of pediatric endocrinology & metabolism : JPEM - 1 Nov 2014

Weber David R, Stanescu Diana E, Semple Robert, Holland Cheryl, Magge Sheela N

Abstract excerpt

Donohue syndrome (DS) is a severe form of congenital insulin resistance due to mutation(s) in the insulin receptor (INSR) gene. Given the similarities between insulin and insulin-like growth factor 1 (IGF-1) receptors, recombinant human IGF-1 (rhIGF-1) has been used to treat severe insulin resistance due to INSR mutation(s). Traditional subcutaneous therapy may be limited by the shortened IGF-1 half-life in these...

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Topics

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Share to Antigens, CD
Share to Infant, Newborn

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Injections, Subcutaneous

Share to Insulin-Like Growth Factor I

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Share to Receptor, Insulin

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Source

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Identifiers

PMID: 25153212
DOI: 10.1515/jpem-2013-0402
PMCID: PMC4535795

Genes

INSR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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