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Article

Mecasermin in Insulin Receptor-Related Severe Insulin Resistance Syndromes: Case Report and Review of the Literature.

International journal of molecular sciences - 24 Apr 2018

Plamper Michaela, Gohlke Bettina, Schreiner Felix, Woelfle Joachim

Abstract excerpt

Mutations in the insulin receptor (INSR) gene underlie rare severe INSR-related insulin resistance syndromes (SIR), including insulin resistance type A, Rabson⁻Mendenhall syndrome and Donohue syndrome (DS), with DS representing the most severe form of insulin resistance. Treatment of these cases is challenging, with the majority of DS patients dying within the first two years of life. rhIGF-I (mecasermin) has...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29695048
DOI: 10.3390/ijms19051268
PMCID: PMC5983765

Genes

INSR
BID

Provenance

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