Article
Decreased half-life of insulin-like growth factor I in Rabson-Mendenhall syndrome.
Journal of inherited metabolic disease - 1 Oct 2001
Longo N, Singh R, Elsas L J
Abstract excerpt
Rabson-Mendenhall syndrome is an autosomal recessive disorder of insulin signalling caused by mutations in the insulin receptor gene. Affected patients are insensitive to exogenous insulin. Insulin-like growth factor I (IGF-I), whose receptor is similar to the one for insulin and is not impaired in this condition, is not always effective in these patients. To understand the reason for this failure, IGF-I...
Topics
- Acanthosis Nigricans
- Child
- Child, Preschool
- Half-Life
- Humans
- Insulin
- Insulin Resistance
- Insulin-Like Growth Factor Binding Protein 3
- Insulin-Like Growth Factor I
- Male
- Mutation
- Receptor, Insulin
- Recombinant Proteins
- Syndrome