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Article

Antithrombin-resistant prothrombin Yukuhashi mutation also causes thrombomodulin resistance in fibrinogen clotting but not in protein C activation.

Thrombosis research - 1 Oct 2014

Takagi Yuki, Kato Io, Ando Yumi, Nakamura Yuki, Murata Moe, Takagi Akira, Murate Takashi, Kojima Tetsuhito

Abstract excerpt

INTRODUCTION: Prothrombin Yukuhashi (p.Arg596Leu) mutation can result in thrombophilia associated with antithrombin (AT) resistance. Mutant thrombin, an active form of prothrombin Yukuhashi, demonstrated moderately lower clotting activity than the wild-type but substantially impaired the formation of the complex with AT. However, the effects of the mutation on the thrombomodulin (TM)-protein C (PC) anticoagulant...

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PMID: 25149909
DOI: 10.1016/j.thromres.2014.07.040

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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