Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular dynamic simulation of the self-assembly of DAP12-NKG2C activating immunoreceptor complex.

PloS one - 1 Jan 2014

Wei Peng, Xu Lida, Li Cheng-Dong, Sun Fu-De, Chen Long, Tan Tianwei, Luo Shi-Zhong

Abstract excerpt

The DAP12-NKG2C activating immunoreceptor complex is one of the multisubunit transmembrane protein complexes in which ligand-binding receptor chains assemble with dimeric signal-transducing modules through non-covalent associations in their transmembrane (TM) domains. In this work, both coarse grained and atomistic molecular dynamic simulation methods were applied to investigate the self-assembly dynamics of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Membrane Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Models, Molecular

Share to Molecular Dynamics Simulation

Share to Multiprotein Complexes

Share to NK Cell Lectin-Like Receptor Subfamily C

Share to Protein Interaction Domains and Motifs

Share to Protein Multimerization

Source

Open in PubMed Open full text

Identifiers

PMID: 25148259
DOI: 10.1371/journal.pone.0105560
PMCID: PMC4141757

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular dynamic simulation of the self-assembly of DAP12-NKG2C activating immunoreceptor complex.PMID 25148259Read ↗

Elucidation of the molecular interactions that enable stable assembly and structural diversity in multicomponent immune receptors.Semantic proximity Read ↗

The activating NKG2D receptor assembles in the membrane with two signaling dimers into a hexameric structure.Semantic proximity Read ↗

The association of polar residues in the DAP12 homodimer: TOXCAT and molecular dynamics simulation studies.Semantic proximity Read ↗

Spatially Resolved In Silico Modeling of NKG2D Signaling Kinetics Reveals Key role of NKG2D and Vav1 Co-clustering in Generating Natural Killer cell ActivationSemantic proximity Read ↗

Understanding the binding mechanisms of Alzheimer risk factor TREM2 in lipid bilayer using multi-scale molecular dynamics simulationsSemantic proximity Read ↗

Insights into the transmembrane helix associations of kit ligand by molecular dynamics simulation and TOXCAT.Semantic proximity Read ↗

Mechanism of tethered agonist-mediated signaling by polycystin-1.Semantic proximity Read ↗

Conformational Plasticity Revealed by the Cocrystal Structure of NKG2D and Its Class I MHC-like Ligand ULBP3Semantic proximity Read ↗

Understanding the conformation transition in the activation pathway of β2 adrenergic receptor via a targeted molecular dynamics simulation.Semantic proximity Read ↗

Deciphering Conformational Changes of the GDP-Bound NRAS Induced by Mutations G13D, Q61R, and C118S through Gaussian Accelerated Molecular Dynamic Simulations.Semantic proximity Read ↗

Activation of Polycystin-1 Signaling by Binding of Stalk-derived Peptide AgonistsSemantic proximity Read ↗

Role of ELA region in auto-activation of mutant KIT receptor: a molecular dynamics simulation insight.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.