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Article

The activating NKG2D receptor assembles in the membrane with two signaling dimers into a hexameric structure.

Proceedings of the National Academy of Sciences of the United States of America - 24 May 2005

Garrity David, Call Matthew E, Feng Jianwen, Wucherpfennig Kai W

Abstract excerpt

The activating NKG2D receptor plays a critical role in innate and adaptive immune responses by natural killer cells and subpopulations of T cells. The human receptor assembles with the DAP10 signaling dimer, and it is thought that one NKG2D homodimer pairs with a single DAP10 dimer by formation of two salt bridges between charged transmembrane (TM) residues. However, direct stoichiometry measurements demonstrated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15894612
DOI: 10.1073/pnas.0502439102
PMCID: PMC1140444

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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