Article
Frequency of TGF- β and IFN- γ genotype as risk factors for acute kidney injury and death in intensive care unit patients.
BioMed research international - 1 Jan 2014
Grabulosa Caren Cristina, Batista Marcelo Costa, Cendoroglo Miguel, Quinto Beata Marie Redublo, Narciso Roberto, Monte Julio Cesar, Durão Marcelino, Rizzo Luiz Vicente, Santos Oscar Fernando Pavão, Dalboni Maria Aparecida
Abstract excerpt
Genetic variations in TGF-β and IFN-γ may interfere with proinflammatory cytokine production and, consequently, may be involved with inflammatory diseases, as acute kidney injury (AKI). We considered that genetic polymorphisms of these cytokines may have a crucial role in the outcome of critically ill patients. To investigate whether the genetic polymorphisms of rs1800470 (codon 10 T/C), rs1800471 (codon 25 C/G)...
Read the complete abstract on PubMed