Article
Stress-induced activation of the sympathoadrenal system is determined by genetic background in rat models of tauopathy.
Journal of Alzheimer's disease : JAD - 1 Jan 2015
Lejavova Katarina, Ondicova Katarina, Horvathova Lubica, Hegedusova Noemi, Cubinkova Veronika, Vargovic Peter, Manz Georg, Filipcik Peter, Mravec Boris, Novak Michal, Kvetnansky Richard
Abstract excerpt
Stress may accelerate onset of neurodegenerative diseases in vulnerable subjects and, vice versa, neurodegeneration affects the responsiveness to stressors. We investigated the neuroendocrine response to immobilization stress in normotensive Wistar-Kyoto rats (WKY), spontaneously hypertensive rats (SHR), and transgenic rats of respective WKY and SHR strains overexpressing human truncated tau protein. Plasma...
Topics
- Animals
- Corticosterone
- Disease Models, Animal
- Epinephrine
- Genetic Predisposition to Disease
- Norepinephrine
- Rats, Inbred SHR
- Rats, Inbred WKY
- Rats, Transgenic
- Restraint, Physical
- Species Specificity
- Stress, Psychological