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Article

Organic cation transporter variation and response to smoking cessation therapies.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco - 1 Dec 2014

Bergen Andrew W, Javitz Harold S, Krasnow Ruth, Michel Martha, Nishita Denise, Conti David V, Edlund Christopher K, Kwok Pui-Yan, McClure Jennifer B, Kim Richard B, Hall Sharon M, Tyndale Rachel F, Baker Timothy B, Benowitz Neal L, Swan Gary E

Abstract excerpt

INTRODUCTION: We evaluated chr6q25.3 organic cation transporter gene (SLC22A1, SLC22A2, SLC22A3) variation and response to smoking cessation therapies. The corresponding proteins are low-affinity transporters of choline, acetylcholine and monoamines, and smoking cessation pharmacotherapies expressed in multiple tissues. METHODS: We selected 7 common polymorphisms for mega-regression analysis. We assessed additive...

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Identifiers

PMID: 25143296
DOI: 10.1093/ntr/ntu161
PMCID: PMC4296186

Variants

rs316019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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