Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association between glycogen synthase kinase-3beta genetic polymorphism and late-onset Alzheimer's disease.

Dementia and geriatric cognitive disorders - 1 Jan 2006

Mateo Ignacio, Infante Jon, Llorca Javier, Rodríguez Eloy, Berciano José, Combarros Onofre

Abstract excerpt

Aberrant phosphorylated tau is the major component of the neurofibrillary tangles in Alzheimer's disease (AD) brains. Glycogen synthase kinase-3beta (GSK-3beta) phosphorylates tau protein, and increased GSK-3beta expression has been associated with neurofibrillary tangles. Saitohin (STH) is a recently identified protein that shares tissue expression pattern with tau, and previous evidence in the Spanish...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Apolipoprotein E4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apolipoproteins E

Share to Glycogen Synthase Kinase 3

Share to Glycogen Synthase Kinase 3 beta

Share to tau Proteins

Source

Identifiers

PMID: 16428884
DOI: 10.1159/000091044

Genes

STH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association between glycogen synthase kinase-3beta genetic polymorphism and late-onset Alzheimer's disease.PMID 16428884Read ↗

Age-dependent association between the Q7R polymorphism in the Saitohin gene and sporadic Alzheimer's disease.Semantic proximity Read ↗

A polymorphic gene nested within an intron of the tau gene: implications for Alzheimer's disease.Semantic proximity Read ↗

The association between single nucleotide polymorphisms of GSK 3β gene and sporadic Alzheimer's disease in a cohort of southern Chinese Han population.Semantic proximity Read ↗

Variation at APOE and STH loci and Alzheimer's diseaseSemantic proximity Read ↗

Common Polymorphisms in the GSK3β Gene May Contribute to the Pathogenesis of Alzheimer Disease: A Meta-Analysis.Semantic proximity Read ↗

Saitohin gene is not associated with Alzheimer's disease.Semantic proximity Read ↗

Is the saitohin gene involved in neurodegenerative diseases?Semantic proximity Read ↗

TAU haplotype and the Saitohin Q7R gene polymorphism do not influence CSF Tau in Alzheimer's disease and are not associated with frontotemporal dementia or Parkinson's disease.Semantic proximity Read ↗

Serotonin transporter and saitohin genes in risk of Alzheimer's disease and frontotemporal lobar dementia: preliminary findings.Semantic proximity Read ↗

Saitohin Q7R polymorphism is associated with late-onset Alzheimer's disease susceptibility among caucasian populations: a meta-analysis.Semantic proximity Read ↗

Association analysis of GSK3B and MAPT polymorphisms with Alzheimer's disease in Han Chinese.Semantic proximity Read ↗

Single-nucleotide polymorphisms of GSK3B, GAB2 and SORL1 in late-onset Alzheimer's disease: interactions with the APOE genotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.