Article
Molecular features and survival outcomes of the intrinsic subtypes within HER2-positive breast cancer.
Journal of the National Cancer Institute - 1 Aug 2014
Prat Aleix, Carey Lisa A, Adamo Barbara, Vidal Maria, Tabernero Josep, Cortés Javier, Parker Joel S, Perou Charles M, Baselga José
Abstract excerpt
BACKGROUND: The clinical impact of the biological heterogeneity within HER2-positive (HER2+) breast cancer is not fully understood. Here, we evaluated the molecular features and survival outcomes of the intrinsic subtypes within HER2+ breast cancer. METHODS: We interrogated The Cancer Genome Atla...
Topics
- Adult
- Aged
- Antineoplastic Agents
- Biomarkers, Tumor
- Breast Neoplasms
- Confounding Factors, Epidemiologic
- DNA Copy Number Variations
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Kaplan-Meier Estimate
- Middle Aged
- Molecular Targeted Therapy