Article
The predictive value of single nucleotide polymorphisms in the VEGF system to the efficacy of first-line treatment with bevacizumab plus chemotherapy in patients with metastatic colorectal cancer: results from the Nordic ACT trial.
International journal of colorectal disease - 1 Jun 2012
Hansen Torben Frøstrup, Christensen René dePont, Andersen Rikke Fredslund, Garm Spindler Karen-Lise, Johnsson Anders, Jakobsen Anders
Abstract excerpt
PURPOSE: Bevacizumab and chemotherapy is a common choice for first-line treatment of metastatic colorectal cancer (mCRC). So far, no predictive markers have been identified. The aim was to investigate the possible predictive value of single nucleotide polymorphisms (SNPs) in the vascular endothelial growth factor (VEGF) system in this setting. METHODS: Pre-treatment blood samples and response evaluations were...
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