Article
Lack of association of intron 3 16 bp polymorphism of TP53 with breast cancer among Iranian-Azeri patients.
Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2014
Pouladi Nasser, Kouhsari Shideh Montasser, Feizi Mohammadali Hosseinpour, Dehghan Roghayeh, Azarfam Parvin, Farajzadeh Davoud
Abstract excerpt
BACKGROUND: p53 gene is a well-known tumor suppressor gene that has several polymorphisms in both its exons and introns. It has been suggested that intron 3 16 bp duplication polymorphism may affect the gene function resulting in reduction or suppression of p53 anti tumor activity. In most case control studies a duplicated allele has been noticeably more frequent in cases rather than controls but there are also...
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