Single nucleotide polymorphisms of ABCC5 and ABCG1 transporter genes correlate to irinotecan-associated gastrointestinal toxicity in colorectal cancer patients: a DMET microarray profiling study.

doi:10.4161/cbt.12.9.17781

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Article

Single nucleotide polymorphisms of ABCC5 and ABCG1 transporter genes correlate to irinotecan-associated gastrointestinal toxicity in colorectal cancer patients: a DMET microarray profiling study.

Cancer biology & therapy - 1 Nov 2011

Di Martino Maria Teresa, Arbitrio Mariamena, Leone Emanuela, Guzzi Pietro Hiram, Rotundo Maria Saveria, Ciliberto Domenico, Tomaino Vera, Fabiani Fernanda, Talarico Danilo, Sperlongano Pasquale, Doldo Patrizia, Cannataro Mario, Caraglia Michele, Tassone Pierfrancesco, Tagliaferri Pierosandro

Abstract excerpt

Recent findings have disclosed the role of UDP-glucuronosyltransferase (UGT) 1A1*28 on the haematological toxicity induced by irinotecan (CPT-11), a drug commonly used in the treatment of metastatic colorectal cancer (mCRC). We investigated the pharmacogenomic profile of irinotecan-induced gastrointestinal (GI) toxicity by the novel drug-metabolizing enzyme and transporter (DMET) microarray genotyping platform....

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PMID: 21892003
DOI: 10.4161/cbt.12.9.17781

Genes

ABCC5
ABCG1

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