Dietary regimens modify early onset of obesity in mice haploinsufficient for Rai1.

Abstract excerpt

Smith-Magenis syndrome is a complex genomic disorder in which a majority of individuals are obese by adolescence. While an interstitial deletion of chromosome 17p11.2 is the leading cause, mutation or deletion of the RAI1 gene alone results in most features of the disorder. Previous studies have shown that heterozygous knockout of Rai1 results in an obese phenotype in mice and that Smith-Magenis syndrome mouse...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Blood Glucose
• Share to Body Fat Distribution
• Share to Body Weight