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Article

Elucidation of structural elements for selectivity across monoamine transporters: novel 2-[(diphenylmethyl)sulfinyl]acetamide (modafinil) analogues.

Journal of medicinal chemistry - 13 Feb 2014

Okunola-Bakare Oluyomi M, Cao Jianjing, Kopajtic Theresa, Katz Jonathan L, Loland Claus J, Shi Lei, Newman Amy Hauck

Abstract excerpt

2-[(Diphenylmethyl)sulfinyl]acetamide (modafinil, (±)-1) is a unique dopamine uptake inhibitor that binds the dopamine transporter (DAT) differently than cocaine and may have potential for the treatment of psychostimulant abuse. To further investigate structural requirements for this divergent binding mode, novel thio- and sulfinylacetamide and ethanamine analogues of (±)-1 were synthesized wherein (1) the...

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Identifiers

PMID: 24494745
DOI: 10.1021/jm401754x
PMCID: PMC3954497

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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