Article
Replication of previous genome-wide association studies of psychiatric diseases in a large schizophrenia case-control sample from Spain.
Schizophrenia research - 1 Oct 2014
Ivorra José Luis, Rivero Olga, Costas Javier, Iniesta Raquel, Arrojo Manuel, Ramos-Ríos Ramón, Carracedo Angel, Palomo Tomas, Rodriguez-Jimenez Roberto, Cervilla Jorge, Gutiérrez Blanca, Molina Esther, Arango Celso, Alvarez Mar, Pascual Juan C, Pérez Víctor, Saiz Pilar Alejandra, García-Portilla María Paz, Bobes Julio, González-Pinto Ana, Zorrilla Iñaki, Haro Josep María, Bernardo Miguel, Baca-García Enrique, González José Carlos, Hoenicka Janet, Moltó María Dolores, Sanjuán Julio
Abstract excerpt
Genome wide association studies (GWAS) has allowed the discovery of some interesting risk variants for schizophrenia (SCZ). However, this high-throughput approach presents some limitations, being the most important the necessity of highly restrictive statistical corrections as well as the loss of statistical power inherent to the use of a Single Nucleotide Polymorphism (SNP) analysis approach. These problems can...
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