Article
Prion propagation can occur in a prokaryote and requires the ClpB chaperone.
eLife - 13 Aug 2014
Yuan Andy H, Garrity Sean J, Nako Entela, Hochschild Ann
Abstract excerpt
Prions are self-propagating protein aggregates that are characteristically transmissible. In mammals, the PrP protein can form a prion that causes the fatal transmissible spongiform encephalopathies. Prions have also been uncovered in fungi, where they act as heritable, protein-based genetic elements. We previously showed that the yeast prion protein Sup35 can access the prion conformation in Escherichia coli....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.