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Article

The role of nibrin in doxorubicin-induced apoptosis and cell senescence in Nijmegen Breakage Syndrome patients lymphocytes.

PloS one - 1 Jan 2014

Alster Olga, Bielak-Zmijewska Anna, Mosieniak Grazyna, Moreno-Villanueva Maria, Dudka-Ruszkowska Wioleta, Wojtala Aleksandra, Kusio-Kobiałka Monika, Korwek Zbigniew, Burkle Alexander, Piwocka Katarzyna, Siwicki Jan K, Sikora Ewa

Abstract excerpt

Nibrin plays an important role in the DNA damage response (DDR) and DNA repair. DDR is a crucial signaling pathway in apoptosis and senescence. To verify whether truncated nibrin (p70), causing Nijmegen Breakage Syndrome (NBS), is involved in DDR and cell fate upon DNA damage, we used two (S4 and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25119968
DOI: 10.1371/journal.pone.0104964
PMCID: PMC4132076

Genes

ATM
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25119968-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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The role of nibrin in doxorubicin-induced apoptosis and cell senescence in Nijmegen Breakage Syndrome patients lymphocytes.PMID 25119968Read ↗

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