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Article

Circulating T Cells of Patients with Nijmegen Breakage Syndrome Show Signs of Senescence.

Journal of clinical immunology - 1 Feb 2017

Meijers Ruud W J, Dzierzanowska-Fangrat Katarzyna, Zborowska Magdalena, Solarska Iwona, Tielemans Dennis, van Turnhout Bob A C, Driessen Gertjan, van der Burg Mirjam, van Dongen Jacques J M, Chrzanowska Krystyna H, Langerak Anton W

Abstract excerpt

PURPOSE: The Nijmegen breakage syndrome (NBS) is an inherited genetic disorder characterized by a typical facial appearance, microcephaly, growth retardation, immunodeficiency, and a strong predisposition to malignancies, especially of lymphoid origin. NBS patients have a mutation in the NBN gene which involves the repair of DNA double-strand breaks (DSBs). Here we studied the peripheral T cell compartment of NBS...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28000062
DOI: 10.1007/s10875-016-0363-5
PMCID: PMC5325864

Genes

NBN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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